KLF14: Genetic Master Switch For Obesity Discovered By Scientists

By on May 16, 2011 in Health, Science Comments

A recent study, published in the journal Nature Genetics, revealed KLF14 gene as a genetic link between diabetes and cholesterol that controls other genes in body fats, that can help in treating obesity-related diseases.

KLF14
KLF14: Master switch for obesity
Image Credit: uscnk.com

According to Tim Spector, leader of the study from King’s College London, “This is the first major study that shows how small changes in one master regulator gene can cause a cascade of other metabolic effects in other genes.”

Based on the study, scientist have identified KLF14 as the genetic link that serves as the master switch to the genes of type 2 diabetes and cholesterol levels.

The Spector’s team conducted a sampling analysis of more than 20,000 genes in fat samples under the skin of 800 British female twin volunteers. A link between the KLF14 gene and the levels of other distant genes were found by the researchers in fat tissue. The findings was confirmed through the analysis of additional 600 fat samples from a separate group of people from Iceland.

Other reports say that more than half a billion people, or one in 10 adults worldwide, are obese.

Type 2 diabetes, often linked with poor diet and lack of exercise, is on the rise and has reached epidemic levels worldwide.



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